Crosslinking, Labeling and Protein Modification
Medchemexpress LLC Methyltetrazine-PEG5-NHS ester | 1802907-92-1 | 97.0% | C24H31N5O9 | 50 MG
Methyltetrazine-PEG5-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. This product is for research use only.
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins
- Purity of 97.0%
Medchemexpress LLC TCO-PEG5-maleimide | 00-00-0 | 99.5% | 583.67 g/mol | C28H45N3O10 | 5 MG
TCO-PEG5-maleimide is a PEG-based PROTAC linker and click-chemistry reagent containing a trans-cyclooctene (TCO) group that reacts via inverse electron-demand Diels-Alder (iEDDA) with tetrazine-functionalized partners. It also features a maleimide moiety for thiol conjugation and is supplied as a high-purity solid in small research pack sizes.
- Contains a trans-cyclooctene (TCO) reactive group for inverse electron-demand Diels-Alder (iEDDA) click reactions.
- Includes a PEG5 spacer to enhance solubility and linker flexibility.
- Features a maleimide group for selective conjugation to thiol groups.
- Offered as high-purity material (reported ~99.5%).
- Available in small milligram pack sizes suitable for research use.
- Store sealed at -20°C; in solvent, store at -80°C for long-term stability.
Medchemexpress LLC S-acetyl-dPEG8-NHS ester | 1070798-99-0 | MFCD11041104 | >97.0% | 597.7 g/mol | C25H43NO13S | 50 MG
dPEG8-SATA (S-acetyl-dPEG8-NHS ester) is a heterobifunctional polyethylene glycol reagent used to introduce a protected thiol group onto biomolecules via NHS-ester chemistry. The hydrophilic dPEG8 spacer provides defined spacing and aqueous solubility, while the SATA protecting group allows controlled deprotection to liberate a free thiol for downstream conjugation and crosslinking applications.
- Provides a protected thiol for controlled thiolation.
- Reacts via NHS-ester chemistry for efficient amine labeling.
- Hydrophilic spacer improves solubility in aqueous media.
- Defined spacer length reduces steric hindrance in conjugates.
- High purity suitable for bioconjugation workflows.
- Available in multiple pack sizes for laboratory use.
Medchemexpress LLC Tamra-PEG2-maleimide | 2304558-24-3 | MFCD31811449 | 95.0% | 640.68 g/mol | C35H36N4O8 | 5 MG
TAMRA-PEG2-Maleimide is a thiol-reactive fluorescent dye comprising a tetramethylrhodamine core connected via a PEG2 spacer to a maleimide moiety. It enables covalent labeling of cysteine residues for fluorescence-based assays, imaging, and bioconjugation workflows, and is supplied as a solid with specified purity and storage recommendations.
- Thiol-reactive maleimide group for selective cysteine labeling.
- Tetramethylrhodamine fluorophore for red fluorescence applications.
- PEG2 spacer improves solubility and reduces steric hindrance.
- High purity for consistent labeling performance.
- Soluble in DMSO; handle under low-light conditions.
- Suitable for protein, peptide, and biomolecule conjugation.
Cayman Chemical Prostaglandin E2-PEG11-biotin
An affinity probe which allows PGE2 to be detected or immobilized using the biotin ligand; the PEG11 moiety serves as a hydrophilic spacer
TARGETMOL CHEMICALS INC CL-C6-PEG4-O-CH2COOH 50MG
Also available in 5 mg 10 mg 100 mg and bulk. Please contact Fisher for quotes. Cl-C6-PEG4-O-CH2COOH (PROTAC Linker 4) is an effective pegylated PROTAC linker which is often used in PROTAC synthesis of chloroanes (HaloPROTACs). purity: 99%
![Medchemexpress LLC 4,7,10,13-tetraoxahexadecanediamide, N1,N16-bis[3-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-3-oxopropyl] | 2182601-68-7 | 97.4% | 810.93 | C48H50N4O8 | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000204012.png-250.jpg)
Medchemexpress LLC 4,7,10,13-tetraoxahexadecanediamide, N1,N16-bis[3-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-3-oxopropyl] | 2182601-68-7 | 97.4% | 810.93 | C48H50N4O8 | 25 MG
DBCO-PEG4-DBCO is a PEG-based bifunctional dibenzocyclooctyne (DBCO) linker that enables strain-promoted alkyne-azide cycloaddition (SPAAC) for copper-free click chemistry. It contains two DBCO groups connected by a PEG4 spacer, is supplied as a white-to-yellow solid, and is used as a cleavable linker in ADC and PROTAC synthesis.
- enables copper-free SPAAC (strain-promoted alkyne-azide cycloaddition)
- contains two DBCO reactive groups connected by a PEG4 spacer
- high purity: 97.4% (HPLC)
- molecular weight: 810.93 g/mol
- supplied as a white-to-yellow solid with recommended sealed, moisture-free storage
Broadpharm Azido-PEG5-Val-Cit-PAB-OH, 500 mg, 98% purity, Cleavable linker, Enzymatic cleavage with Val-Cit, Azide reactive group
Azido-PEG5-Val-Cit-PAB-OH, 500 mg, 98% purity, Cleavable linker, Enzymatic cleavage with Val-Cit, Azide reactive group
eMolecules 635287-26-2 | Fmoc-NH-PEG5-CH2COOH | MFCD26142982 | 1g
Ambeed | Fmoc-NH-PEG5-CH2COOH | 1g | 506391038 | A474989 | 635287-26-2 | MFCD26142982 | 517.575 | C27H35NO9
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Medchemexpress LLC Cy5-PEG-biotin | 95.0% | 10 MG
Cy5-PEG-biotin (MW 2000) is a polyethylene glycol conjugate that combines a Cy5 fluorescent dye with biotin for fluorescent labeling and affinity capture. Supplied in a small quantity vial for research use.
- Cy5 fluorophore enables red/NIR fluorescence detection.
- Biotin provides high-affinity binding to streptavidin/avidin for capture and pull-down assays.
- PEG spacer (approx. MW 2000) improves solubility and reduces steric hindrance.
- Purity ≥95% as supplied.
- Store sealed, away from moisture and light; in solvent: -80°C up to 6 months, -20°C up to 1 month.
Medchemexpress LLC Dspe-peg-amine (ammonium) | 474922-26-4 | 98.8% | 1000 (average) | (C2H4O)nN2O10P·NH3 | 25 MG
DSPE-PEG-Amine (average MW 1000, ammonium salt) is a PEGylated phospholipid with a terminal primary amine used to functionalize liposomes and nanoparticles. The hydrophobic DSPE anchor incorporates into lipid bilayers while the PEG spacer presents a reactive amine at the particle surface for covalent conjugation to ligands, dyes, or biomolecules in delivery and surface-modification applications.
- PEGylated phospholipid with terminal primary amine.
- Average molecular weight approximately 1000 daltons.
- Ammonium salt form to aid handling and solubility.
- Enables covalent conjugation to NHS-esters, aldehydes, and other activated groups.
- Integrates into liposome bilayers for surface functionalization.
- Suitable for nanoparticle coating and targeted delivery research.
Cayman Chemical AdenosIn amIn congenr 10mg
An adenosine A1 receptor agonist; selectively binds adenosine A1 over A2A and A3 receptors (Kis = 0.85, 210, and 281 nM, respectively, for the rat receptors); increases survival and prevents neuronal damage in the hippocampal CA1 region in a gerbil model of bilateral carotid artery occlusion-induced cerebral ischemia at 75 UG/kg; protects against auditory threshold shifits and inner and outer hair cell loss in rats following noise exposure at 110 dB at 100 UG/kg
Medchemexpress LLC TCO-PEG-TCO (MW 5000) | 97.1% | 100 MG
TCO-PEG-TCO (MW 5000) is a PEG-based PROTAC linker designed for the synthesis of PROTACs. This click chemistry reagent contains a TCO group, enabling it to undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules that contain Tetrazine groups.
- PEG-based PROTAC linker for targeted protein degradation.
- Facilitates click chemistry reactions with Tetrazine groups.
- Utilizes the intracellular ubiquitin-proteasome system.
eMolecules 1263044-40-1 | Medchem Express | Biotin-PEG3-OH | 50mg | 781212818 | HY-135924 | 375.48 | C16H29N3O5S
AstaTech | 28-DICHLOROQUINOLINE-3-CARBOXALDEHYDE | 1g | 200610555 | 52861 | 97.000 | 144918-96-7 | MFCD06202349 | 226.060 | C10H5Cl2NO
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eMolecules Cholesterol-PEG-MAL, MW 1,000 | Broadpharm |667.932 | C39H61N3O6 | 0.000 | CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@H](CC[C@]4(C)[C@H]3CC[C@]12C)OC(=O)NCCOCCNC(=O)CCN1C(=O)C=CC1=O | 50mg | 649281004
Cholesterol-PEG-MAL, MW 1,000 | Broadpharm |667.932 | C39H61N3O6 | 0.000 | CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@H](CC[C@]4(C)[C@H]3CC[C@]12C)OC(=O)NCCOCCNC(=O)CCN1C(=O)C=CC1=O | 50mg | 649281004